Latest data reinforces the safety of COVID-19 vaccinations in pregnant women
Vaccinated women who gave birth between January and October 2021 had a very similar low risk of stillbirth, low birth weight, and premature birth compared to women who were not vaccinated in pregnancy, according to the latest data from The UK Health Security Agency (UKHSA).
Previous studies have shown the risk of being severely ill with COVID-19 is higher for unvaccinated women. Out of 235 pregnant women who were admitted to intensive care with COVID-19 between January and September 2021, none had received two doses of vaccine.
The latest analysis shows that women who had received at least one dose of COVID-19 vaccine during their pregnancy and gave birth between April and October 2021 were more likely to give birth without any of the reported adverse outcomes than women who had not been vaccinated in pregnancy (92.9% compared with 91.6%). This difference was more apparent in those aged 30 years and older.
The stillbirth rate for vaccinated women who gave birth was approximately 3.6 per 1,000, a similar rate for women who were not vaccinated in pregnancy (3.9 per 1,000).
The proportion of vaccinated women giving birth to babies with low birth weight (5.01%) was lower than the proportion for women who were not vaccinated in pregnancy (5.33%).
The proportion of premature births was 5.97% for vaccinated women, similar to the 5.88% in women who were not vaccinated in pregnancy.
Vaccine coverage has been increasing overall – in August 2021, 22.5% of women giving birth had received at least one dose of vaccine. This increased to 32.1% of women who gave birth in September, and 41.3% in October 2021, almost doubling in 2 months. Of women who gave birth in October 2021, 29.4% had received 2 doses of the vaccine.
Despite the marked increase in coverage in recent months, women of Black ethnicity and women living in the most deprived areas in England were least likely to have been vaccinated in pregnancy. A total of 13.3% of pregnant Black women and 18.3% of pregnant women living in more deprived areas of England had a first dose of a COVID-19 vaccine by time of delivery – up from 5.5% and 7.8% respectively in the last published statistics in November.
However, just 6.8% of pregnant Black women and only 10.2% of pregnant women living in more deprived areas of England had two doses, compared with 23.4% of white women and 34.8% living in less deprived areas.
Dr. Gayatri Amirthalingam, Consultant Epidemiologist at UKHSA, said:
There is growing evidence indicating that if you are pregnant, you are at increased risk of serious illness from COVID-19, especially in late pregnancy.
We know that the COVID-19 vaccines used in the UK are highly effective at protecting against hospitalisation and our ongoing monitoring of the vaccine programme continues to provide reassuring evidence on the safety of COVID-19 vaccines in pregnant women.
I would urge all pregnant women to come forward and get their vaccine without delay. This is the best way to protect you and your baby.
Professor Lucy Chappell, Chief Scientific Adviser at the Department of Health and Social Care and a consultant obstetrician, said:
“It’s really promising to see the number of pregnant women who were vaccinated at time of birth almost doubling in just two months and should be hugely reassuring for other women thinking about getting the jab.
“The data also show that outcomes for babies continue to be reassuringly similar for vaccinated pregnant women compared to unvaccinated pregnant women.
“The vaccines are the best possible way for a pregnant woman to protect herself and her baby – we urge pregnant women to get their vaccine, whether it’s their first dose, second dose, or booster, as soon as you can.”
Dr Edward Morris, President of the Royal College of Obstetricians and Gynaecologists, said:
“We hope that this increase in uptake will reassure and encourage other pregnant women who have not yet been vaccinated to come forward for their first, second or booster doses.
“We know that pregnant women are more vulnerable of becoming seriously ill with COVID-19, which can lead to an increased risk of giving birth prematurely, and stillbirth. We have high-quality evidence that the COVID-19 vaccine is the best way to protect both pregnant women and their babies against COVID-19.
“We remain concerned that those living in the most deprived areas of England and women of Black ethnicity were the least likely to be vaccinated before giving birth, and we continue to advocate for concerted efforts to support these women to feel more confident about having the vaccine.”